Forty-year, time-varying GCM integrations have been run both with and without coupled chemistry. The results suggest that while computer resources preclude multi-member ensemble experiments with coupled chemistry models to achieve statistical significance, robust results can be achieved for some atmospheric parameters by running ensemble experiments with imposed ozone changes.
On the design of practicable numerical experiments to investigate stratospheric temperature change
Peer Reviewed
Atmospheric Science Letters 6, Issue 2, pages 123-127, 2005, 10.1002/asl.101.